SOCS3 anticorps

N° du produit ABIN7119605

L’anticorps Lapin Polyclonal anti-SOCS3 a été validé pour WB, IHC, ELISA, IF et IP. Il convient pour détecter SOCS3 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SOCS3 anticorps (ABIN7119605)

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-SOCS3 anticorps

Fonction: SOCS3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: suppressor of cytokine signaling 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3

Sujet:

Synonyms: Suppressor of cytokine signaling 3 (SOCS-3)|Cytokine-inducible SH2 protein 3 (CIS-3)|STAT-induced STAT inhibitor 3 (SSI-3)|SOCS3|CIS3|SSI3

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo(By similarity). Probable substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST(By similarity).

Poids moléculaire: 30 kDa

ID gène: 9021

UniProt: O14543

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C